Q. Gao

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

This study uses scRNA-seq to analyze B-ALL samples, revealing transcriptional heterogeneity and developmental origins, with specific subtypes associated with distinct cell populations and clinical outcomes.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis

This study examines transcriptional plasticity in Mycobacterium tuberculosis across diverse environmental conditions and identifies genetic factors influencing it.

Protein language model-based end-to-end type II polyketide prediction without sequence alignment

This study introduces DeepT2, a machine learning model that predicts type II polyketides from KS{beta} sequences without alignment, using NLP techniques and metagenomics/metabolomics data.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

Drug degradation caused by mce3R mutations confers contezolid (MRX-I) resistance in Mycobacterium tuberculosis

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

Physiology and structure of pathogenic Escherichia coli pOmpT reveal two substrate-binding sites

The paper identifies two substrate-binding sites in pOmpT that enable specific cleavage of human AMP RNase 7, revealing structural basis for substrate specificity and drug development clues.

Immunological findings in a group of individuals who were non-responders to standard two-dose SARS-CoV-2 vaccines

The paper compares immunological characteristics of SARS-CoV-2 vaccine non-responders aged 18-59 and 60+ to identify factors associated with seroconversion and recommend booster vaccinations.

Mapping pediatric brain tumors to their origins in the developing cerebellum

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

Isolation and characterization of fucosylated extracellular vesicles based on a novel high-throughput GlyExo-Capture technique

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

This study shows host casein kinase 1 phosphorylates a viral phosphoprotein, altering its phase separation and affecting virus infection.

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

How alginate lyase produces quasi-monodisperse oligosaccharides: a normal mode analysis-based docking and molecular dynamics simulation study

This study uses normal mode analysis and molecular dynamics simulations to investigate how alginate lyase produces quasi-monodisperse oligosaccharides by analyzing conformational changes and enzyme flexibility.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

This study shows GSTZ1 enhances sorafenib-induced ferroptosis in HCC by inhibiting the NRF2/GPX4 axis, and its deficiency leads to resistance to sorafenib.

The expression of PDCD1 and CD274 in T cells and macrophages correlated positively with COVID-19 severity

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

Feasibility of Integrating Canine Olfaction with Chemical and Microbial Profiling of Urine to Detect Lethal Prostate Cancer

This study tests the feasibility of using canine olfaction, VOC analysis, and microbial profiling in urine to detect lethal prostate cancer, showing 71% sensitivity and 70-76% specificity.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Intracellular accumulation and secretion of hydrophobin-enriched vesicles aid the rapid sporulation of molds

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.