Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity
C. Fare, K. Rhine, A. Lam, S. Myong, J. Shorter
This study identifies the minimal functional domain of Kapβ2 required for preventing and reversing prion-like domain-mediated aggregation of disease-linked RNA-binding proteins.
bioRxiv · Sep 14, 2022 · PreprintBiochemistry