A. Lam

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.

Cell intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow

The paper images and models plasma membrane dynamics during cytokinesis in leukemia cells, revealing mechanical regulation of membrane accumulation at the cleavage furrow.

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.

Rational development of a small-molecule activator of CK1γ2 that decreases C99 and beta-amyloid levels

This study identifies CK1γ2 as a therapeutic target for Alzheimer's disease by showing its activation reduces C99 and beta-amyloid levels through increased PS1-Ser367 phosphorylation.

Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity

This study identifies the minimal functional domain of Kapβ2 required for preventing and reversing prion-like domain-mediated aggregation of disease-linked RNA-binding proteins.

A survey to assess animal methods bias in scientific publishing

The paper surveys scientists and reviewers to assess biases in favor of animal-based methods in scientific publishing, finding that nonanimal studies are often requested to include animal data.

Single-cell monitoring of dry mass and dry density reveals exocytosis of cellular dry contents in mitosis

The paper develops a single-cell method to monitor dry mass and density during mitosis, revealing exocytosis-driven changes in cellular composition.

Single virus assay reveals membrane determinants and mechanistic features of Sendai virus binding

This study uses a single virus assay to investigate Sendai virus binding mechanisms, identifying receptor structural features, cooperative binding, cholesterol dependence, and a rolling mobility mechanism.

Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

This study shows that inhibiting BKCa channels in neonatal cardiomyocytes protects against myocardial ischemia-reperfusion injury, unlike in adult hearts where activation provides protection.

Dietary vitamin B12 reduces amyloid-β proteotoxicity by alleviating oxidative stress and mitochondrial dysfunction

This study shows dietary vitamin B12 reduces Aβ proteotoxicity in C. elegans by improving mitochondrial function and reducing oxidative stress without affecting Aβ accumulation.

Plasmid transmitted small multidrug resistant (SMR) efflux pumps differ in gene regulation and enhance tolerance to quaternary ammonium compounds (QAC) when grown as biofilms

This study examines SMR efflux pump gene regulation and QAC tolerance in biofilms, finding that biofilm growth enhances QAC tolerance for most SMR genes.

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening

This paper develops a cardiac fibrosis-on-a-chip model that recapitulates fibrosis hallmarks and enables drug screening for anti-fibrotic therapies.

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

The paper shows microtubules regulate tau condensation, which spatially controls microtubule severing enzymes and motor movement.