Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization
C. Gaston, S. De Beco, B. Doss, P. Meng, E. Gauquelin, J. D'Alessandro, C. T. Lim, B. Ladoux, D. Delacour
This study shows EpCAM regulates RhoA trafficking via endosomes to control actomyosin dynamics, cell shape, and polarity in epithelial cells.
bioRxiv · Apr 19, 2020Cell Biology