Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis
D. L. E. Vergoossen, J. J. Plomp, C. Gstottner, Y. E. Fillie-Grijpma, R. Augustinus, R. Verpalen, M. Wuhrer, P. W. H. I. Parren, E. Dominguez-Vega, S. M. van der Maarel, J. J. Verschuuren, M. G. Huijbers
This study shows that monovalent anti-MuSK IgG4 antibodies enhance pathogenicity in myasthenia gravis compared to their bivalent form.
bioRxiv · Sep 24, 2020Immunology