Structure of VanS from Vancomycin-Resistant Enterococci: A Sensor Kinase with Weak ATP Binding
K. C. Grasty, C. Guzik, E. J. D'Lauro, S. B. Padrick, J. Beld, P. J. Loll
The paper presents X-ray structures of VanS CA domains from VRE types A and C, revealing weak ATP binding with low millimolar KD values, suggesting a regulatory mechanism for resistance gene expression.
bioRxiv · Dec 12, 2022Biochemistry