Author

J. Beld

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

P. J. Loll· 3 shared E. J. D'Lauro· 2 shared K. C. Grasty· 2 shared P. Rotsides· 2 shared A. A. Rashad· 1 shared A. Dick· 1 shared A. N. Talarico· 1 shared B. Blackburne· 1 shared

Activity by Year

2022-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiochemistry

P. J. Loll

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth

A. Dick, M. J. Reginato, J. Beld, N. L. Simone, S. Cocklin, A. A. Rashad, A. N. Talarico, J. Merzy, R. G. Young, L. Ciraku, E. Esquea

This study identifies and validates two novel ACSS2 inhibitors that cross the blood-brain barrier and reduce breast cancer brain metastasis in vitro and ex vivo.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

Strategic acyl carrier protein engineering enables functional type II polyketide synthase reconstitution in vitro

K. K. Li, Y. I. Cho, M. A. Tran, C. Wiedemann, S. Zhang, R. S. Koweek, N. K. Hoang, G. Hamrick, M. Bowen, B. Kokona, P. Stallforth, J. Beld, U. Hellmich, L. K. Charkoudian

This study enables functional reconstitution of type II PKS in vitro by engineering acyl carrier proteins to be activatable by Sfp.

bioRxiv · Aug 2, 2023Biochemistry

The VanS sensor histidine kinase from type-B VRE recognizes vancomycin directly

L. J. Maciunas, P. Rotsides, E. J. D'Lauro, S. Brady, J. Beld, P. J. Loll

This study shows that type-B VanS from VRE directly interacts with vancomycin, activating its autokinase activity and confirming a direct sensing mechanism for VanS.

bioRxiv · Jul 9, 2023 · PreprintBiochemistry

Acyl-CoA thioesterase-2 facilitates beta-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

C. Bekeova, J. I. Han, H. Xu, E. Kerr, B. Blackburne, S. C. Lynch, C. Mesaros, M. Murgia, R. Vadigepalli, J. Beld, R. Leonardi, N. W. Snyder, E. L. Seifert

This study shows ACOT2 regulates acyl-CoA levels in glycolytic muscle, promoting β-oxidation when lipid supply is low but causing lipid accumulation and poor glucose homeostasis when lipid supply is high.

bioRxiv · Jun 27, 2023 · PreprintBiochemistry

Novel Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins

P. Rotsides, P. J. Lee, N. Webber, K. C. Grasty, J. Beld, P. J. Loll

This paper develops diazirine-based vancomycin photoprobes with improved specificity and fewer chemical modifications for identifying vancomycin-binding proteins.

bioRxiv · Jun 15, 2023Biochemistry

Structure of VanS from Vancomycin-Resistant Enterococci: A Sensor Kinase with Weak ATP Binding

K. C. Grasty, C. Guzik, E. J. D'Lauro, S. B. Padrick, J. Beld, P. J. Loll

The paper presents X-ray structures of VanS CA domains from VRE types A and C, revealing weak ATP binding with low millimolar KD values, suggesting a regulatory mechanism for resistance gene expression.

bioRxiv · Dec 12, 2022Biochemistry