Cancer BiologybioRxiv
Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics
C. H. Hulton, E. A. Costa, N. S. Shah…·J. T. Poirier
This study develops a CRISPR-Cas9 lentiviral platform for genome editing of patient-derived xenografts to analyze genetic dependencies and drug resistance mechanisms in vivo.
DOI 10.1038/s43018-020-0040-8