C. Kisker

Trapped in translocation: Stalling of XPD on a crosslinked DNA substrate

This study uses cryo-EM to reveal how XPD helicase stalls on interstrand crosslinked DNA, identifies functional residues, and suggests a model for NER bubble formation.

How to limit the speed of a motor: The intricate regulation of the XPB ATPase and Translocase in TFIIH

This study investigates how the XPB ATPase in TFIIH is regulated by DNA and the p52/p8 subunits, revealing that p52/p8 acts as a master regulator that both activates and limits XPB's activity.

Structural basis for the activation of CDK7 by MAT1 and Cyclin H

The paper solves the structure of the CAK complex from C. thermophilum and shows MAT1-dependent CDK7 activation independent of T-loop phosphorylation.

Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein

The paper introduces GradR, a method combining RNase treatment and mass spectrometry to discover bacterial RNA-binding proteins, identifying FopA as a new FinO domain RBP with distinct RNA targets.

The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair

This study shows that the TFIIH subunits p44 and p62 form a heterodimer that detects DNA damage during nucleotide excision repair.