An expanded 2-pyridinecarboxaldehyde (2PCA)-based chemoproteomics toolbox for probing protease specificity
H. N. Bridge, C. L. Frazier, A. M. Weeks
This paper introduces two new chemoproteomics tools, PICS2 and CHOPPER, for profiling protease specificity using 2PCA-based reagents, eliminating the need for custom synthesis.
bioRxiv · Feb 12, 2023 · PreprintBiochemistry