Author

A. M. Weeks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. A. Wells· 2 shared J. R. Byrnes· 2 shared A. Ashworth· 1 shared A. L. Brill· 1 shared A. Marson· 1 shared A. Reuter· 1 shared B. Wancewicz· 1 shared C. E. Kaiser· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

J. A. Wells

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Author profile →

4 papers

Recent·Most cited

An expanded 2-pyridinecarboxaldehyde (2PCA)-based chemoproteomics toolbox for probing protease specificity

H. N. Bridge, C. L. Frazier, A. M. Weeks

This paper introduces two new chemoproteomics tools, PICS2 and CHOPPER, for profiling protease specificity using 2PCA-based reagents, eliminating the need for custom synthesis.

bioRxiv · Feb 12, 2023 · PreprintBiochemistry

Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression

J. R. Byrnes, A. M. Weeks, J. Carnevale, E. Shifrut, L. Kirkemo, A. Ashworth, A. Marson, J. A. Wells

This study compares how hypoxia and regulatory T cells affect the CD8+ T cell surface proteome, finding hypoxia has a more significant impact than Treg-mediated suppression.

bioRxiv · Jun 7, 2021Immunology

Human islet expression levels of Prostaglandin E2 synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity

N. A. Truchan, R. J. Fenske, H. K. Sandhu, A. M. Weeks, C. Patibandla, B. Wancewicz, S. Pabich, A. Reuter, J. M. Harrington, A. L. Brill, D. C. Peter, R. Nall, M. Daniels, M. Punt, C. E. Kaiser, , M. E. Kimple

The paper examines the relationship between PGE2 production and β-cell function in non-diabetic obesity, finding that PGE2 synthetic enzymes correlate with β-cell mass and function, while EP3 receptor does not.

bioRxiv · Feb 3, 2021Pharmacology & Toxicology

Mapping proteolytic neo-N termini at the surface of living cells

A. M. Weeks, J. R. Byrnes, I. Lui, J. A. Wells

The paper develops a method to capture and sequence cell surface N termini in live cells, revealing changes in neo-N termini abundance in response to proteolytic stimuli.

bioRxiv · Feb 23, 2020Biochemistry