Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments
V. Opuu, G. Nigro, C. Lazennec, Y. Mechulam, E. Schmitt, T. Simonson
The paper redesigns methionyl-tRNA synthetase to increase activity towards β-methionine using computational protein design and experimental validation.
bioRxiv · Dec 28, 2022Biochemistry