Author

E. Schmitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

Y. Mechulam· 4 shared G. Nigro· 2 shared T. Simonson· 2 shared V. Opuu· 2 shared A. Abi-Khalil· 1 shared A. Bender· 1 shared A. C. Zhu· 1 shared A. des Georges· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

Y. Mechulam

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

S. Hebbar Subramanyam, J. Hriczko, S. Schulz, T. Look, T. Goodarzi, T. Clarner, M. Scheld, M. Kipp, E. Verjans, S. Boell, C. Neullens, I. Costa, Z. Li, L. Gan, B. Denecke, , K. Tenbrock

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

bioRxiv · Jun 29, 2024Immunology

Visualization of translation reorganization upon persistent collision stress in mammalian cells

J. Fedry, J. Silva, M. Vanevic, S. Fronik, Y. Mechulam, E. Schmitt, A. des Georges, W. Faller, F. Förster

The paper visualizes how translation reorganizes in mammalian cells under persistent collision stress, revealing changes in ribosome complexes and quality control mechanisms.

bioRxiv · Mar 23, 2023 · PreprintCell Biology

Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments

V. Opuu, G. Nigro, C. Lazennec, Y. Mechulam, E. Schmitt, T. Simonson

The paper redesigns methionyl-tRNA synthetase to increase activity towards β-methionine using computational protein design and experimental validation.

bioRxiv · Dec 28, 2022Biochemistry

Role of aIF5B in archaeal translation initiation

R. Kazan, G. Bourgeois, C. Lazennec-Schurdevin, E. Larquet, Y. Mechulam, P.-D. Coureux, E. Schmitt

This study investigates the role of aIF5B in archaeal translation initiation, showing it accelerates subunit joining without GTP hydrolysis and reveals structural interactions with aIF1A.

bioRxiv · May 1, 2022Biochemistry

The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation

C. Sepich-Poore, Z. Zheng, E. Schmitt, K. Wen, Z. S. Zhang, X.-L. Cui, Q. Dai, A. C. Zhu, L. Zhang, A. Sanchez Castillo, X. Zhuang, C. He, S. Nachtergaele

This paper identifies the METTL5-TRMT112 complex as the methyltransferase responsible for m6A modification at 18S rRNA, linking it to metabolism and development.

bioRxiv · May 18, 2021Biochemistry

A New Tree-Based Methodological Framework to Infer the Evolutionary History of Mesopolyploid Lineages: An Application to the Brassiceae Tribe (Brassicaceae).

L. Henocq, S. Gallina, E. Schmitt, V. Castric, X. Vekemans, C. Poux

This paper introduces a tree-based method to infer the evolutionary history of mesopolyploid lineages, applied to the Brassiceae tribe, resolving phylogenetic relationships among species and parental lineages.

bioRxiv · Jan 9, 2020 · PreprintEvolutionary Biology

Adaptive landscape flattening allows the design of both enzyme:substrate binding and catalytic power

V. Opuu, G. Nigro, E. Schmitt, Y. Mechulam, T. Simonson

This paper designs an enzyme to bind transition state analogs using adaptive landscape flattening, achieving accurate predictions of catalytic activity and reaction rates.

bioRxiv · Sep 18, 2019Biochemistry

Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells

C. Fonti, A. Saumet, A. Abi-Khalil, B. Orsetti, W. Jacot, E. Cleroux, A. Bender, M. Dumas, E. Schmitt, J. Colinge, M. Weber, C. Sardet, S. du Manoir, C. Theillet

This study shows that activating different oncogenes in human mammary epithelial cells leads to distinct genetic and epigenetic changes, suggesting oncogene activation shapes breast cancer subtypes.

bioRxiv · Jun 11, 2018Cancer Biology