Lactoferricins access the cytosol of Escherichia coli within few seconds
E. F. Semeraro, L. Marx, J. Mandl, I. Letofsky-Papst, C. Mayrhofer, M. P. K. Frewein, H. L. Scott, S. Prevost, H. Bergler, K. Lohner, G. Pabst
This study shows lactoferricin-derived AMPs rapidly enter E. coli cytosol within seconds, leading to metabolic shutdown, with membrane damage being a secondary effect.
bioRxiv · Sep 24, 2021 · PreprintBiophysics