Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration
Jae‐Jin Song, Hyejin Park, YuRee Choi, Taekyung Ryu, Jisu Shin, Seo-Hyun Kim, Albert Park, Justin Wang, Devanik Biswas, Shih-Ching Chou, Shinwon Ha, Yura Jang, Yu Jung Shin, Hao Wen Chen, Ingie Hong, , Tae‐In Kam
This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.
bioRxiv · Mar 4, 2026 · PreprintNeuroscience