Author

Shinwon Ha

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:snRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ted M. DawsoniD· 4 shared Valina Lynn DawsoniD· 4 shared Juan Carlos TroncosoiD· 3 shared Sung-Ung KangiD· 3 shared Jinhee ParkiD· 2 shared Albert Park· 1 shared Bardia Nezami· 1 shared Beth O. Van Emburgh· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Ted M. DawsonORCID

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4 papers

Recent·Most cited

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

Jae‐Jin Song, Hyejin Park, YuRee Choi, Taekyung Ryu, Jisu Shin, Seo-Hyun Kim, Albert Park, Justin Wang, Devanik Biswas, Shih-Ching Chou, Shinwon Ha, Yura Jang, Yu Jung Shin, Hao Wen Chen, Ingie Hong, , Tae‐In Kam

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

bioRxiv · Mar 4, 2026 · PreprintNeuroscience

Microglial Lag3 Drives α-Synuclein--induced Neurotoxic Activated (A1) Astrocytes and Neurodegeneration

Xiuli Yang, Ramhari Kumbhar, Bo Am Seo, Shinwon Ha, Jared T. Hinkle, Ning Wang, Shuya Li, Lili Niu, Haiqing Liu, Nicolas Stanciu, Rong Chen, Yasuyoshi Kimura, Enquan Xu, Fangyi Cheng, Sung-Ung Kang, , Xiaobo Mao

This study identifies microglial Lag3 as a key receptor linking extracellular α-synuclein PFF recognition to neurotoxic astrocyte conversion and dopaminergic neurodegeneration.

bioRxiv · Jan 6, 2026 · PreprintNeuroscience

Neuronal PARIS-STAT3 axis drives tau pathology and glial activation in Alzheimers disease

Ji-Yang Song, Fatih Akkentli, Heejin Jo, Jinhee Park, Shinwon Ha, Jos� Ochoa, Juan Carlos Troncoso, Sung-Ung Kang, Valina Lynn Dawson, Ted M. Dawson

This study shows that PARIS in neurons activates STAT3, leading to tau pathology and glial activation in Alzheimer's disease, and identifies the PARIS-STAT3 pathway as a therapeutic target.

bioRxiv · Dec 10, 2025 · PreprintNeuroscience

Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)

Sung-Ung Kang, Jinhee Park, Shinwon Ha, Dongsan Kim, Olga Pletniková, Javier Redding‐Ochoa, Juan Carlos Troncoso, Quan Peng, Beth O. Van Emburgh, Jaldhir Trivedi, Saurav Brahmachari, Bardia Nezami, Valina Lynn Dawson, Ted M. Dawson

This study uses HiF-snRNA-seq to analyze the cingulate cortex in Parkinson's disease and Parkinson's disease dementia, identifying cell-type-specific gene expression changes and disease-stage-related pathways.

bioRxiv · Mar 1, 2025 · PreprintGenomics