IL-12/IL23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum
R. Yadav, M. Vague, M. Rettig, C. P. Loo, K. Brown, A. Samiea, J. M. Moreau, A. G. Ortega-Loayza
This study uses spatial transcriptomics to analyze lesional skin from PG patients before and after IL-12/IL-23 blockade, revealing complex inflammation patterns and treatment-resistant B cell infiltration.
bioRxiv · Apr 26, 2024 · PreprintImmunology