K. Brown

IL-12/IL23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum

This study uses spatial transcriptomics to analyze lesional skin from PG patients before and after IL-12/IL-23 blockade, revealing complex inflammation patterns and treatment-resistant B cell infiltration.

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

A novel ilarvirus protein is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing

This study identifies a novel ilarvirus protein, CP-RT, produced via stop codon readthrough, which suppresses RNA silencing and is essential for persistent infection.

Incorporation of collagen into Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia pseudomallei biofilms enhances their elasticity and resistance against phagocytic clearance

This study shows that incorporating collagen into biofilms of Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia pseudomallei increases their elasticity and resistance to phagocytosis.

Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

The paper identifies MAT2A as a critical host factor for BKPyV infection through a CRISPR/Cas9 screen and shows a small molecule inhibitor of MAT2A is a potent antiviral drug.

A transmission chain linking Mycobacterium ulcerans with Aedes notoscriptus mosquitoes, possums and human Buruli ulcer cases in southeastern Australia

The paper investigates the transmission chain of Mycobacterium ulcerans between mosquitoes, possums, and humans in southeastern Australia, finding a significant association between M. ulcerans and Aedes notoscriptus mosquitoes.

Genomic regions and candidate genes affect root anatomical traits in diverse rice accessions

This study identifies genomic regions and candidate genes affecting root anatomical traits in rice using genome-wide association analyses.

Assessing changes in global fire regimes

This study assesses changes in global fire regimes using expert opinions, finding increased fire regime change rates and future intensification under higher emission scenarios.

Influence of root cortical aerenchyma on the rhizosphere microbiome of field-grown maize

This study investigates how root cortical aerenchyma (RCA) affects rhizosphere microbial communities in maize, finding RCA explains more variance in microbial composition in South Africa than genotype.

Bacterial mechanosensing of surface stiffness promotes signaling and growth leading to biofilm formation by Pseudomonas aeruginosa

This study shows that Pseudomonas aeruginosa responds to surface stiffness through mechanosensing, affecting signaling, growth, and biofilm formation.

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

This study reveals the scaffold-client model of PRC1 condensate assembly through phase separation, showing how CBX2 acts as a scaffold and other subunits influence condensate properties and composition.

Identification of RNA virus-derived RdRp sequences in publicly available transcriptomic datasets

The paper identifies RNA virus-derived RdRp sequences in transcriptomic datasets, expanding known viral diversity and providing curated HMM profiles for virus discovery.

Arginase 1 is a key driver of immune suppression in pancreatic cancer

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

This study compares the antigenic properties of SARS-CoV-2 Omicron variants BA.4 and BA.5 with BA.1, BA.2, and vaccine-induced antibodies, finding they are antigenically distinct and show enhanced neutralisation breadth after breakthrough infection.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning

The paper validates a deep learning method that predicts breast cancer biomarkers from H&E slides with high accuracy in a clinical setting.

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

Prioritising the eradication of invasive species from island archipelagos with high reinvasion risk

This paper develops a prioritization method for island invasive species eradication that accounts for reinvasion risk, showing it improves conservation outcomes in case studies.

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

Activation of GPR116/ADGRF5 by its tethered agonist requires key amino acids in extracellular loop 2 of the transmembrane domain

This study identifies key amino acids in extracellular loops 2/3 and transmembrane7 of GPR116 that are critical for tethered agonist-mediated activation.

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

hC9ORF78 localizes to kinetochores and is required for proper chromosome segregation.

This study identifies hC9ORF78 as a kinetochore-associated protein required for proper chromosome segregation, revealing its mitotic function and subcellular localization.

Choosing optimal trigger points for ex situ, in toto conservation of single population threatened species

The paper develops a decision-support tool to determine optimal trigger points for ex situ conservation of single population threatened species, using retrospective case studies to illustrate its application.

Nodal root diameter and node number in maize (Zea mays L.) interact to influence plant growth under nitrogen stress

The paper examines how nodal root diameter and number in maize interact to affect plant growth under nitrogen stress, finding that fewer, thicker roots improve performance in low nitrogen conditions.

Host response to cholestyramine can be mediated by the gut microbiota

This study shows cholestyramine affects host metabolism through changes in gut microbiota, identifying specific microbes that mediate its beneficial effects.

Shared genetic architecture underlying root metaxylem phenotypes under drought stress in cereals

The paper identifies genes associated with root metaxylem phenotypes in maize and rice under drought and non-stress conditions using cross-species GWAS and gene co-expression networks.

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

This study shows that SARS-CoV-2-specific T-cell immunity remains robust six months after infection, with response magnitude linked to initial infection severity.

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.