Modeling Cell-Specific Dynamics and Regulation of the Common Gamma Chain Cytokines
A. M. Farhat, A. C. Weiner, C. Posner, Z. S. Kim, B. Orcutt-Jahns, S. M. Carlson, A. S. Meyer
The paper builds a dynamical model of common gamma-chain cytokines to predict ligand responses and shows receptor trafficking and tensor factorization are essential for accurate modeling and engineering cell-specific responses.
bioRxiv · Mar 19, 2020Immunology