Alpha-Synuclein is a Target of Fic-mediated Adenylylation/AMPylation: Implications for Parkinson’s Disease
S. Mattoo, A. Sanyal, S. Dutta, A. Chandran, A. Koller, A. Camara, B. G. Watson, R. Sengupta, D. Ysselstein, P. Montenegro, J. R. Cannon, C. Rochet
The paper identifies alpha-Synuclein as a target of HYPE-mediated adenylylation, showing it reduces Syn aggregation and ER stress in Parkinson’s disease models.
bioRxiv · Jan 21, 2019Biochemistry