CD4+ T Cell Depletion Before Primary Dengue and/or Secondary Zika Infection Reveals Mechanistic Correlates of Antibody Functionality in Rhesus Macaques.
C. Serrano-Collazo, A. M. Miranda, L. A. Cruz, S. Henein, M. R. Sanchez-Rosado, L. Alvarez, T. Arana, M. I. Martinez, C. Roman, A. Burgos, A. M. de Silva, C. A. Sariol
This study shows that CD4+ T cell depletion before DENV infection affects antibody specificity and cross-reactivity during subsequent ZIKV infection in rhesus macaques.
bioRxiv · Feb 22, 2024 · PreprintImmunology