Cancer BiologybioRxiv
Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity
M. Hafner, C. E. Mills, K. Subramanian…·P. Sorger
This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.
DOI 10.1016/j.chembiol.2019.05.005