Author

P. Sorger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:imaging· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2

Frequent Co-Authors

S. Santagata· 4 shared J.-R. Lin· 3 shared Y.-A. Chen· 3 shared C. Yapp· 2 shared R. Rashid· 2 shared Z. Maliga· 2 shared A. C. Palmer· 1 shared A. J. Martinot· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

S. Santagata

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

M. Kalocsay, Z. Maliga, A. J. Nirmal, R. J. Eisert, G. A. Bradshaw, I. H. Solomon, Y.-A. Chen, R. J. Pelletier, C. A. Jacobson, J. Mintseris, R. F. Padera, A. J. Martinot, D. H. Barouch, S. Santagata, P. Sorger

The paper uses multiplexed proteomics and imaging to compare inflammatory and thrombotic responses in resolving SARS-CoV-2 infection in rhesus macaques and lethal COVID-19 in humans.

bioRxiv · Oct 14, 2020 · PreprintPathology

Online narrative guides for illuminating tissue atlas data and digital pathology images

R. Rashid, Y.-A. Chen, J. Hoffer, J. L. Muhlich, J.-R. Lin, R. Krueger, H. Pfister, R. Mitchell, S. Santagata, P. Sorger

The paper discusses the need for interactive guides to help interpret complex tissue atlas data and digital pathology images, using Minerva software as an example.

bioRxiv · Mar 27, 2020 · PreprintScientific Communication & Education

Comparing the efficacy of cancer therapies between subgroups in basket trials

A. C. Palmer, D. Plana, P. Sorger

This paper uses permutation testing to compare cancer therapy efficacy across subgroups in basket trials, identifying missed therapeutic benefits in specific mutations.

bioRxiv · Jan 14, 2020Cancer Biology

Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer

R. Rashid, G. Gaglia, Y.-A. Chen, J.-R. Lin, Z. Du, Z. Maliga, D. Schapiro, C. Yapp, J. Muhlich, A. Sokolov, P. Sorger, S. Santagata

The paper describes a dataset of multiplexed immunofluorescence images and single-cell immune marker data from human tonsil and lung cancer tissues, along with analysis methods and tools.

bioRxiv · Jul 17, 2019Cancer Biology

Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity

M. Hafner, C. E. Mills, K. Subramanian, C. Chen, M. Chung, S. A. Boswell, R. A. Everley, C. Liu, C. S. Walmsley, D. Juric, P. Sorger

This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.

bioRxiv · Mar 19, 2019Cancer Biology

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

J.-R. Lin, B. Izar, S. Mei, S. Wang, P. Shah, C. Yapp, S. Santagata, P. Sorger

This paper introduces t-CyCIF, a method for highly multiplexed immunofluorescence imaging of FFPE tissues using conventional microscopes, and demonstrates its application in analyzing tumor antigens and immune markers.

bioRxiv · May 10, 2018Cancer Biology