C. Chen

Phase Separation and Ageing of Glycine-Rich Protein from Tick Adhesive

This study investigates the phase separation and ageing of glycine-rich protein from tick saliva, showing it forms biomolecular condensates and undergoes liquid-to-gel transitions.

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

The olfactory receptor SNIF-1 mediates foraging for leucine-rich diets in Caenorhabditis elegans

This study identifies SNIF-1 as an olfactory receptor in C. elegans that mediates foraging for leucine-rich diets via the AWC neurons in response to isoamyl alcohol.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery.

This study identifies WDR62's role in regulating purine metabolism via the HSP70/HSP90 chaperone network, linking its dysfunction to microcephaly through metabolic enzyme instability.

Integrin-deficient T cell leukemia accumulates in the central nervous system

This study shows that integrin-deficient T-cell leukemia accumulates in the CNS and proliferates faster, suggesting integrins normally restrict T-ALL growth there, and integrin blockade could enhance chemotherapy.

Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging

This study uses ecological analysis of hypoxia and acidosis biomarkers to improve prediction of DCIS upstaging by identifying habitat-based metabolic phenotypes and spatial niches.

Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals

This paper develops a digital immunoassay for rapid detection of SARS-CoV-2 antibodies in multiple animal species with high sensitivity and specificity.

Chemically induced cell plasticity enables the generation of high-fidelity embryo model

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

Extracellular plant subtilases dampen cold shock peptide elicitor levels

The paper shows that the plant subtilase SBT5.2a cleaves the bacterial cold-shock protein csp22, reducing its immunogenicity and pathogen growth.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

This study shows that down-regulating AKT proteins slows mutant-KRAS pancreatic tumor growth more effectively than inhibiting AKT kinase activity.

High glucose treatment induced nuclei aggregation of microvascular endothelial cells via foxo1a-klf2a pathway

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern

This paper develops a CRISPR/Cas9 system for efficient gene editing and overexpression in the fern Ceratopteris richardii, demonstrating functional effects on stomatal and photosynthetic traits.

ROS Mediated the Photodynamic Antibacterial of Vibrio vulnificus by a DNA-Targeted Molecular Rotor Probe

This paper introduces a novel fluorescent probe, BDTP, that effectively kills Vibrio vulnificus through photodynamic antibacterial activity and promotes wound healing in an animal model.

Extracellular electron transfer drives efficient H2-independent methylotrophic methanogenesis by Methanomassiliicoccus, a seventh order methanogen

This study shows Methanomassiliicoccus uses extracellular electron transfer for efficient methylotrophic methanogenesis, enhancing methane production in coculture with electrogenic bacteria.

Characterisation of cuticle mechanical properties: analysing stiffness in layered living systems to understand surface buckling patterns

The paper measures mechanical properties of plant cuticle layers during growth to understand how they influence surface buckling patterns in Hibiscus trionum flower petals.

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

This study identifies shallow-water chemosymbiotic clams as a significant, previously overlooked carbon sink in the Yellow Sea, contributing 43% of the region's sedimental carbon burial.

Lineage-tracing of Acta2+ cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblasts to myofibroblast reversible switch

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

The paper identifies OsNF-YB7 as a repressor of chlorophyll biosynthesis in rice embryos by inhibiting OsGLK1, contrasting its role with LEC1 in Arabidopsis.

Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants

This study shows that DNA prime-protein boost elicits enhanced antibodies against non-RBD regions of SARS-CoV-2, improving cross-neutralization against variants in mice.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Cross-species genomic survey reveals a single origin of the soft-shelled turtles

This study reveals that soft-shelled turtles have a single origin of their ZW-type sex chromosomes, coinciding with the Paleocene-Eocene thermal maximum.

Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos

This study identifies circatidal gene expression rhythms in the deep-sea shrimp Rimicaris leurokolos, revealing a 12-hour oscillation pattern distinct from circadian rhythms and similar to ultradian rhythms in other species.