FeS-cluster coordination of vertebrate thioredoxin regulates suppression of hypoxia-induced factor 2α through iron regulatory protein 1
C. Berndt, E.-M. Hanschmann, L. M. Jordt, M. Gellert, L. Thewes, C. Ortegon Salas, G. Poschmann, C. S. Mueller, Y. Bodnar, S. Schippers, O. Handorf, R. Nowack, J.-M. Moulis, C. Schulzke, V. Schuenemann, C. H. Lillig
The paper shows FeS-cluster coordination of Trx1 regulates hypoxia-induced factor 2α suppression via IRP1 by linking redox and iron homeostasis.
bioRxiv · Aug 4, 2020 · PreprintBiochemistry