scRNA-seq analysis of colon and esophageal tumors uncovers abundant microbial reads in myeloid cells undergoing proinflammatory transcriptional alterations
W. Robinson, J. K. Stone, F. Schischlik, B. Gasmi, M. C. Kelly, C. Seibert, K. Dadkhah, E. M. Gertz, J. S. Lee, K. Zhu, L. Ma, X. W. Wang, C. Sahinalp, R. Patro, M. D. Leiserson, , E. Ruppin
The paper develops a computational pipeline to identify microbial reads in scRNA-seq data and finds that microbial reads are enriched in myeloid cells with proinflammatory transcriptional changes.
bioRxiv · May 14, 2020 · PreprintCancer Biology