J. S. Lee

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

This study identifies how SARS-CoV-2 evolves to counteract host interferon signaling through interactions with autophagy pathways.

The paper shows nuclear rupture is common in cancer, especially glioblastoma, and links it to lamin proteins and immune signaling.

The paper identifies 3-hydroxy-kynurenine as a tryptophan metabolite that enhances host survival during bacterial infection by modulating kainate receptors in macrophages.

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

This study shows that a compensatory RNase E mutation in P. aeruginosa increases siderophore production and macrophage ferroptosis, contributing to virulence and potentially being targeted by gallium therapy.

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

The paper identifies a 48-gene prognostic signature and synthetic-lethality profiles predictive of survival and therapy response in mesothelioma using transcriptomic and exomic data from 122 patients.

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

This study tests the efficacy of double-stranded RNA targeting VP1 to control and prevent sacbrood virus in Apis cerana apiaries, showing increased survival rates and safe mitigation of the virus.

This paper identifies a short ERK5 isoform that promotes extranuclear localization of active ERK5, driving EMT and poor survival in breast cancer.

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

The paper uses apathogenic FIV transmission data to predict pathogenic FeLV transmission dynamics in Florida panthers, showing comparable accuracy to traditional methods.

This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.

This study shows that SENP2 suppresses white adipose tissue browning by modulating C/EBPβ, leading to increased thermogenic gene expression and resistance to obesity in mice.

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

The paper screens FDA-approved drugs against SARS-CoV-2 in different cell types, identifying three FDA-approved antivirals with potential for clinical use.

The paper develops a computational pipeline to identify microbial reads in scRNA-seq data and finds that microbial reads are enriched in myeloid cells with proinflammatory transcriptional changes.

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

The paper quantifies synthetic lethality in normal tissues and links it to cancer risk, onset, and tumor suppressor specificity using GTEx transcriptomics data.

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

The paper identifies p53, KRAS, and VHL mutations as being selected during CRISPR-Cas9 editing through computational and experimental analysis.

This study identifies circadian PER2 amplitude enhancement in endothelial cells as a novel cardioprotective strategy that mimics HIF1A metabolic adaptation during myocardial ischemia.

The paper compares genomic features between African American and European American lung cancers, finding higher genomic instability and homologous recombination-deficiency in African American tumors.