The interface of condensates of the hnRNPA1 low complexity domain promotes formation of amyloid fibrils
M. Linsenmeier, L. Faltova, U. Capasso Palmiero, C. Seiffert, A. M. Kueffner, D. Pinotsi, J. Zhou, R. Mezzenga, P. Arosio
This study shows that amyloid fibrils form at the interface of hnRNPA1 condensates, not uniformly within them, and that surfactants can inhibit this process.
bioRxiv · May 23, 2022 · PreprintBiophysics