Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function
N. Bramey, M. C. Melo-Narvaez, F. See, B. Ballester-Llobell, C. Steinchen, E. Jain, K. Hafner, A. O. Yildirim, M. Koenigshoff, M. Lehmann
This study shows that primary human lung fibroblasts from different disease origins exhibit similar susceptibility to senescence induction but distinct senescent programs, which impair alveolar epithelial progenitor function.
bioRxiv · Jul 24, 2023 · PreprintCell Biology