M. Lehmann

Flavonoid metabolism and its different physiological roles in plant cold acclimation

This study investigates the role of flavonoid metabolism in plant cold acclimation, showing distinct effects on metabolism and protein homeostasis in early and late stages.

Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

Claudin-4 polymerizes after the incorporation of just two extracellular claudin-3 residues

This study identifies key residues in claudin-4 that enable polymerization when supplemented with claudin-3 residues, enhancing tight junction formation and barrier function.

Ergosterol mediates aggregation of natamycin in the yeast plasma membrane

This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.

Synthesis and characterization of novel intrinsically fluorescent analogs of cholesterol with improved photophysical properties.

This paper presents novel intrinsically fluorescent cholesterol analogs with improved photophysical properties for live-cell imaging of sterol transport.

Degradation of Fatty Acid Export Protein1 by Rhomboid-Like Protease11 Contributes to Cold Tolerance in Arabidopsis

The paper shows that RBL11-mediated degradation of FAX1 is critical for cold tolerance in Arabidopsis.

Universal DNA methylation age across mammalian tissues

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

This study shows that primary human lung fibroblasts from different disease origins exhibit similar susceptibility to senescence induction but distinct senescent programs, which impair alveolar epithelial progenitor function.

OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

The paper introduces OrgaMapper, a workflow for analyzing organelle positioning, demonstrating its robustness against common challenges in assessing positioning phenotypes.

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis

This study identifies fibroblast-derived extracellular vesicles containing SFRP1 that contribute to pulmonary fibrosis and suggests SFRP1 as a therapeutic target.

Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures

This study identifies IL11 as a key mediator of aberrant epithelial differentiation in ILD fibroblast-epithelial crosstalk using a 3D organoid co-culture model and secretome analysis.

Spatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles

The paper maps spatial and functional interactions between virus and host proteins in intact cytomegalovirus particles using cross-linking mass spectrometry and proteomics.

The molecular organization of flat and curved caveolae indicates bendable structural units at the plasma membrane.

This study identifies proteins involved in regulating caveolae shape using imaging techniques, revealing that dynamin is not directly involved in caveolae curvature.

Water column stability as an important factor controlling nitrite-dependent anaerobic methane oxidation in stratified lake basins

The paper investigates nitrite-dependent anaerobic methane oxidation in two lake basins, finding that stable low redox conditions are necessary for Candidatus Methylomirabilis to thrive, while fluctuating conditions hinder its growth.

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualization

The paper introduces sulfonated rhodamines as impermeable dyes for cell surface protein labeling, validated in live cell imaging and STED nanoscopy.

Archaeogenomics of a ~2,100-year-old Egyptian leaf provides a new timestamp on date palm domestication

The paper analyzes an ancient date palm leaf to determine the timing of gene flow from wild relatives to domesticated date palms, finding hybridization occurred at least 2,100 years ago.

Polymerization of misfolded protein lowers CX3CR1 expression in human PBMCs

This study shows that polymerized misfolded Z-AAT protein reduces CX3CR1 expression on human PBMCs, suggesting a role for extracellular misfolded proteins in immune regulation.

Molecular and spectroscopic characterization of green and red cyanine fluorophores from the Alexa Fluor and AF series

The paper characterizes the molecular structures and spectroscopic properties of Alexa Fluor and AF series dyes using spectroscopy, mass spectrometry, and molecular dynamics simulations.

Soil nutrient availability alters tree carbon allocation dynamics during drought

This study shows that soil nutrient availability mitigates drought stress in trees by enhancing root metabolism and carbon allocation to belowground tissues.

Deuterated rhodamines for protein labelling in nanoscopy

This paper introduces deuterated rhodamines for improved fluorescence microscopy applications, showing enhanced photophysical and chemical properties.

Transcriptional response of the calcification and stress response toolkits in an octocoral under heat and pH stress

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Comparative proteomics of octocoral and scleractinian skeletomes and the evolution of coral calcification

This study compares proteomic profiles of coral and octocoral skeletomes to investigate the molecular mechanisms of calcium carbonate polymorph formation in corals.

Manganese/iron-supported sulfate-dependent anaerobic oxidation of methane by archaea in lake sediments

The paper demonstrates sulfate-dependent anaerobic methane oxidation by Candidatus Methanoperedens archaea in lake sediments, with metal oxides supporting the process under sulfate-starved conditions.

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.