Author

C. V. Pagba

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Biochemistry· 1

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

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A. A. Gorfe· 1 shared A. K. Gupta· 1 shared A. Naji· 1 shared D. van der Hoeven· 1 shared H. Liang· 1 shared J. F. Hancock· 1 shared K.-J. Cho· 1 shared M. J. McCarthy· 1 shared

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2018-2018 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. A. Gorfe

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1 paper

Recent·Most cited

BiochemistrybioRxivOct 11, 2018

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

M. J. McCarthy, C. V. Pagba, P. Prakash…·A. A. Gorfe

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.

DOI 10.1021/acsomega.8b03308

humanproteomics