H. Liang

Pressorum Sensing: Growth-induced Compression Activates cAMP Signaling in Pseudomonas aeruginosa

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Nanoclustering and signaling of KRAS G12C and KRAS G12D respond to lipid acyl chain remodeling in an allele-specific manner

This study shows that KRAS G12C and G12D mutants respond differently to lipid acyl chain remodeling, affecting their nanoclustering and signaling activities.

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Urea amidolyase as the enzyme for urea utilization in algae: functional display in Chlamydomonas reinhardtii and evolution in algae

This study identifies urea amidolyase (UAD) as the key enzyme for urea utilization in algae, showing its functional importance and evolutionary distribution in Chlamydomonas reinhardtii.

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

The impact of Arctic environments on human cerebral blood flow

This study examines changes in cerebral blood flow in Arctic conditions and finds reduced velocity and increased pulsatility in specific arteries.

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

The paper identifies MTMR proteins as regulators of KRAS function by controlling plasma membrane phospholipid levels, specifically PI4P and PtdSer.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers

This paper demonstrates CRISPR-Cas9 can selectively target somatic mutations in pancreatic cancer by exploiting PAMs in noncoding regions, achieving >80% cell death with minimal off-target effects.

Simultaneous CRISPR-Cas9-induced double strand breaks are lethal in models of pancreatic cancer

This study shows CRISPR-Cas9-induced DNA double-strand breaks are more cytotoxic to pancreatic cancer cells than radiation-induced breaks, with significant tumor growth inhibition and chromosomal instability.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

Diversity and ecological function of urease-producing bacteria in the cultivation environment of Gracilariopsis lemaneiformis

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

A novel pathway of functional microRNA uptake and mitochondria delivery

The paper identifies RNA phase separation as a novel pathway for extracellular miRNA uptake and shows that these miRNAs are delivered to mitochondria via PNPT1.

Redox signaling regulates breast cancer metastasis via HIF1alpha-stimulated EMT dynamics and metabolic reprogramming

This study shows that GPx2 loss in mammary tumors enhances metastasis through HIF1-driven EMT and metabolic changes, identified via scRNA-seq.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

Structural and mechanistic insights into the MCM8/9 helicase complex

This study reports the structure of the MCM8/9 helicase complex using cryo-EM, revealing its DNA unwinding mechanism through conformational changes and rotary motions.

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

A Resident State Allows Influenza Polymerase to Smoothly Switch between Transcription and Replication Cycles

This study identifies a resident state in influenza polymerase that enables smooth transitions between transcription and replication cycles through structural analysis.

The OPAQUE1/DISCORDIA2 myosin XI is required for phragmoplast guidance during asymmetric cell division in maize

This study identifies OPAQUE1 as essential for phragmoplast guidance during asymmetric cell division in maize, showing it interacts with kinesins to ensure proper cytokinesis.