Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons
E. D. Mock, B. Vallin, W. McGuinness, M. C. Caiazza, M. Lavelle, B. Jenkins, M. Rokicki, A. Koulman, J. Monzon Sandoval, C. Webber, B. J. Ryan, R. Wade-Martins
This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.
bioRxiv · Nov 2, 2026 · PreprintCell Biology