Cell BiologybioRxivPreprint
Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons
E. D. Mock, B. Vallin, W. McGuinness…·R. Wade-Martins
This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.