The crystal structure and localization of Trypanosoma brucei invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage
A. Casas-Sanchez, S. Perally, R. Ramaswamy, L. R. Haines, C. Rose, C. Yunta, M. Aguilera-Flores, M. J. Lehane, I. C. Almeida, M. J. Boulanger, A. Acosta-Serrano
The paper identifies and characterizes a novel family of invariant surface proteins in the metacyclic stage of Trypanosoma brucei, suggesting a more permissive VSG coat structure that may aid vaccine development.
bioRxiv · Nov 26, 2018 · PreprintMicrobiology