Author

C. Rose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Acosta-Serrano· 4 shared A. Casas-Sanchez· 3 shared M. J. Lehane· 3 shared S. Jhunjhunwala· 2 shared S. Perally· 2 shared A. A. Cass· 1 shared A. J. Beckett· 1 shared A.-J. Tong· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

A. Acosta-Serrano

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Author profile →

6 papers

Recent·Most cited

Graph-pMHC: Graph Neural Network Approach to MHC Class II Peptide Presentation and Antibody Immunogenicity

W. J. Thrift, J. Perera, S. Cohen, N. Lounsbury, H. Gurung, C. Rose, J. Chen, S. Jhunjhunwala, K. Liu

The paper introduces graph-pMHC, a graph neural network for predicting MHC Class II peptide presentation and improves antibody immunogenicity risk prediction.

bioRxiv · Jan 19, 2023Immunology

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

R. P. Kozak, K. Mondragon-Shem, C. Williams, C. Rose, S. Perally, G. Caljon, J. van den abbeele, K. Wongtrakul-Kish, R. Gardner, D. Spencer, M. J. Lehane, A. Acosta-Serrano

The paper characterizes the N-glycan profile of tsetse salivary glycoproteins and shows they bind trypanosomes and are recognized by C-type lectins.

bioRxiv · Jun 25, 2020Biochemistry

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

A. Acosta-Serrano, M. Sterkel, L. Haines, A. Casas-Sanchez, V. Owino, R. Vionette-Amaral, S. Quek, C. Rose, M. Silva dos Santos, N. Garcia Escude, H. Ismail, M. I. Paine, S. M. Barribeau, S. Wagstaff, J. I. MacRae, , P. L. Oliveira

This study shows that nitisinone can kill tsetse flies without harming bees, offering an eco-friendly method to control African trypanosomiasis transmission.

bioRxiv · Jun 8, 2020Biochemistry

Trypanosoma brucei colonises the tsetse gut via an immature peritrophic matrix in the proventriculus

C. Rose, N. A. Dyer, A. Casas-Sanchez, A. J. Beckett, C. Solorzano, B. Middlehurst, M. Marcello, M. J. Lehane, I. A. Prior, A. Acosta-Serrano

This study shows Trypanosoma brucei colonizes the tsetse gut via the immature peritrophic matrix in the proventriculus, not directly through the midgut PM.

bioRxiv · Jan 7, 2019Microbiology

The crystal structure and localization of Trypanosoma brucei invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage

A. Casas-Sanchez, S. Perally, R. Ramaswamy, L. R. Haines, C. Rose, C. Yunta, M. Aguilera-Flores, M. J. Lehane, I. C. Almeida, M. J. Boulanger, A. Acosta-Serrano

The paper identifies and characterizes a novel family of invariant surface proteins in the metacyclic stage of Trypanosoma brucei, suggesting a more permissive VSG coat structure that may aid vaccine development.

bioRxiv · Nov 26, 2018 · PreprintMicrobiology

Transposable Element Expression In Tumors Is Associated With Immune Infiltration And Increased Antigenicity

Y. Kong, C. Rose, A. A. Cass, M. Darwish, S. Lianoglou, P. M. Haverty, A.-J. Tong, C. Blanchette, I. Mellman, R. Bourgon, G. John, S. Jhunjhunwala, M. L. Albert, H. Chen-Harris

The paper shows that transposable element expression in tumors correlates with immune infiltration and increased antigenicity, suggesting potential synergy with immunotherapy.

bioRxiv · Aug 9, 2018Cancer Biology