Central Glucagon-Like Peptide-1 Agonism Ameliorates Colonic Inflammation in a Murine Model of Inflammatory Bowel Disease
Biren Desai, Kendra L. Francis, Caeley L. Bryan, Jessie Connolly, THANUSHREE KARUNAGARAN, Sara Mathan, Karina Sharma, Vincent M. Damian, Christina A. Watts, Pique P. Choi, KELLY H. KADLEC, Bao Anh Phan, Maria Cristina Pacheco, Kimberly M. Alonge, Gregory J. Morton, , Jarrad M. Scarlett
This study shows that central GLP-1 receptor activation reduces colonic inflammation in a mouse model of IBD, independent of peripheral effects.
bioRxiv · Oct 24, 2026 · PreprintNeuroscience