Identification and SAR optimization of FBXO22-mediated TEAD Targeted Glue degraders
Martin Fisher, Alice Fletcher, Callum Hamby, Jack Miles, Martin Ambler, Aleksandra Azevedo, Sara Bisetto, Colin T. R. Davies, Pauline Drouhin, Liliana Greger, Scott J. Hughes, Martin O'Rourke, Dominic D. G. Owens, Paula MacGregor, Wojciech J. Stec, , Marta Carrara
This study identifies and optimizes TEAD-targeted glue degraders using an aldehyde-mediated degron mechanism, achieving improved degradation potency and kinetics.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology