Author
University of TorontoORCID 0000-0001-6194-4636Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Martin Fisher, Alice Fletcher, Callum Hamby…·Marta Carrara
This study identifies and optimizes TEAD-targeted glue degraders using an aldehyde-mediated degron mechanism, achieving improved degradation potency and kinetics.
Scott J. Hughes, Wojciech J. Stec, Colin T. R. Davies…·Andrea Testa
The paper identifies a potent BRD9 degrader, AMPTX-1, which selectively recruits BRD9 to DCAF16, leading to its degradation in vivo.
Yan Nie, John R. Tabor, Jianping Li…·C.H. Arrowsmith
This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.
Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi…·C.H. Arrowsmith
The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.
Matthew E. R. Maitland, Gabriel Onea, Dominic D. G. Owens…·Caroline Schild‐Poulter
The paper shows that the CTLH E3 ligase complex regulates substrate selectivity and autoregulation by exchanging its β-propeller subunits WDR26 and muskelin.
Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar…·Marella F. T. R. De Bruijn
The paper examines how dynamic chromatin boundaries around the Runx1 gene influence its expression during hematopoietic development in mice.