Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations
Anna Burato, Alessio Di Clemente, Camilla Lodetti, Valentino Panico, Giulio Pistorio, Beatriz Eymi Pimentel Mizusaki, Beatrice Pastore, Marco Zattoni, Luigi Celauro, Lucia Zanetti, Lorenca Sadiraj, Eugenio Piasini, Michèle Giugliano, Katja Reinhard, Giuseppe Legname
Lifelong prion protein (PrP) loss in mice lowers excitatory synaptic proteins, makes network bursts in mature cortical cultures rarer and neuronal activity more correlated, and increases adult dimming-disk escapes.
bioRxiv · Sep 29, 2026 · PreprintMolecular Biology✦ In-depth digest