Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma
David M. Gau, Pooja Chawla, Kexin Xu, Niharika Welling, Jacob Antonello, Caroline Consoli, Monica H. Wei, Sara Zdancewicz, Michael DaSilva, Chris Varghese, Paul G. Francoeur, Haibin Shi, Xucai Chen, Anurag N. Paranjape, Flordeliza S. Villanueva, , Partha Sarathi Roy
This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.
Journal of Biological Chemistry · Dec 11, 2025Peer-reviewedCell Biology