Partha Sarathi Roy

This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.

The paper describes the Hope for Others rapid autopsy program for metastatic breast cancer, detailing its protocols, sample collection, and findings on metastasis research and model development.

This study shows that MRTF in breast cancer cells promotes osteoclast differentiation via paracrine signaling, enhancing bone metastasis, and suggests MRTF inhibition as a potential therapeutic strategy.

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.

This study identifies mDia2 as a mediator of MRTF-A-dependent breast cancer cell migration and links MRTF activity to malignancy, suggesting it as a therapeutic target.

This study shows that partial loss of Profilin1 in vascular endothelial cells has some protective effects against atherosclerosis but is not enough to fully prevent it.