Diverse Intestinal Injuries Drive Heterogeneous Transcriptional Responses and Limited Reactivation of Developmental Gene Programs in Human Enteroids
Jonathan Villanueva, Yu-Hwai Tsai, Angeline Wu, Carson Caldwell, Abigail Vallie, Mira Buerk, Sha Huang, Jason R. Spence
This study examines how human enteroids respond to various injuries, finding limited reactivation of developmental gene programs and highlighting the role of specific signaling pathways.
bioRxiv · Aug 24, 2026 · PreprintCell Biology