Paternal epigenetic inheritance encoded by sperm histones shapes offspring prenatal development and viability
Tia M Hoisington, Belicia Guzman, Amanda J Brown, Carson J Black, Ellie Ikemura, Haben Haile, Mustika Rahmawati, Marika Van Slageren, Gabriella Searle, Jaqueline A. Meza, Nathan C. Law
This study shows that paternal sperm histone H3K27me3 marks influence offspring development and viability by affecting organ and tissue formation.
bioRxiv · Oct 30, 2026 · PreprintDevelopmental Biology