Gene Regulatory Network Inference reveals tcf4 as a key a player in neuroblastoma gene expression circuitry
Catherine Koering, Elodie Vallin, Franck Picard, Sandrine Gonin-Giraud, Olivier Gandrillon
Mechanistic stochastic gene regulatory network inference on neuroblastoma tumoroid scRNA-seq predicts TCF4 as a hub whose loss slows chromaffin-to-sympathoblast progression, supported by JQ1 treatment ex vivo.
bioRxiv · Oct 12, 2026 · PreprintCancer Biology✦ In-depth digest