Author

Laura Broutier

Lyon 1 UniversitéORCID 0000-0001-5163-5573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Catherine Koering· 2 shared Eddy PasquieriD· 2 shared Marion Le GrandiD· 2 shared Olivier GandrilloniD· 2 shared Valéry AttignoniD· 2 shared Adrien Bertrand‐ChapeliD· 1 shared Alexandra BomaneiD· 1 shared Alexandre VasiljeviciD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Catherine Koering

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologyPLoS Computational BiologyPeer-reviewedMar 31, 2026

Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short-range diffusive process

Thi Nhu Thao Nguyen, Catherine Koering, Elodie Vallin…·Olivier Gandrillon

This study uses a multiscale agent-based model to show that short-range diffusive signaling among stem cells is critical for reproducing the spatial structure of neuroblastoma tumoroids.

1 citation

humanspatial transcriptomics

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Cancer BiologybioRxivPreprintJan 9, 2026

Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma

Marion Le Grand, Chen Buxbaum, Mathilde Kerhervé…·Eddy Pasquier

This study identifies IRAK1 as a chemoresistance factor in neuroblastoma and shows synergy between IRAK1 inhibition and various drugs in preclinical models.

DOI 10.64898/2026.01.09.697473

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintAug 28, 2024

MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1: implications for MYC-induced safeguard mechanisms and cancer

Xingjie Ma, Athanasios Tsalikis, Mathieu Vernier…·David Bernard

This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.

1 citation

humanexperimental assay

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Cancer BiologyeLifePeer-reviewedNov 23, 2023

BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

Paul Huchedé, Swann Meyer, Clément Berthelot…·Marie Castets

This study shows BMP2 and BMP7 work with H3.3K27M to create a quiescent yet invasive state in pediatric gliomas.

11 citations

humanbulk RNA-seq

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