Lipoproteins modulate the uptake and biological functionof cationic cell-penetrating peptides across the animal lineage.
Sovanny R. Taylor, Temilade V. Oluwasesin, Muthu Raj Salaikumaran, Borna Novak, Adam Briner, Roshan Ailani, Pilar I. Andrade, Paulo L. Onuchic, Olivia M. S. Carmo, Garam Kım, Jacob A. Blum, Mason Galliver, Catherine Stuart, Nicolás Méndez, Vedant Patel, , Steven Boeynaems
This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.
bioRxiv · Aug 24, 2026 · PreprintCell Biology