Computer-Assisted Systematic Chemical-Space Mapping of a First-in-Class Peripherally Restricted α2AAR Agonist through Scaffold-Seeded Enumeration
Cedric Moore, Larry Zhu, Zane Cheng
The paper uses scaffold-seeded enumeration to explore chemical space around a first-in-class 2AAR agonist, identifying active compounds with analgesic effects.
bioRxiv · Oct 18, 2026 · PreprintPharmacology & Toxicology