Author

Zane Cheng

San Francisco VA Medical CenterORCID 0000-0002-4371-0104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Anat LevitiD· 1 shared Brian K. ShoichetiD· 1 shared Cedric Moore· 1 shared Cheng-Guo WuiD· 1 shared Chia‐Ling TuiD· 1 shared Fangyu LiuiD· 1 shared Georgios SkiniotisiD· 1 shared Isabella GlenniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

Anat LevitORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 18, 2026

Computer-Assisted Systematic Chemical-Space Mapping of a First-in-Class Peripherally Restricted α2AAR Agonist through Scaffold-Seeded Enumeration

Cedric Moore, Larry Zhu, Zane Cheng

The paper uses scaffold-seeded enumeration to explore chemical space around a first-in-class 2AAR agonist, identifying active compounds with analgesic effects.

DOI 10.64898/2026.09.16.751790

statistical modeldrug response / drug discovery

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BiophysicsSciencePeer-reviewedSep 19, 2024

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

Fangyu Liu, Cheng-Guo Wu, Chia‐Ling Tu…·Georgios Skiniotis

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

58 citationstop 1%

humanstructural biology

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