Multifaceted fusion defects converge on altered mitochondrial distribution and increased mutant mitofusin level in CMT2A models
OLENA O. VARUK, Amandine Ruiz, Celia Orengo, Amelie Cozzolino, Paul de Boissier, Aı̈cha Aouane, Thomas Rival
This study investigates how different CMT2A mutations affect mitochondrial distribution and mutant mitofusin levels in Drosophila models, revealing a spectrum of dominant effects linked to disease severity.
bioRxiv · Mar 14, 2025 · PreprintCell Biology